The purpose of the study was to evaluate the suspending property of various suspending agent and to select a cheap, effective alternative natural suspending agent for pharmaceutical suspensions. Comparative study between suspending agents like kollidon CL-M like tragacanth, acacia, hydroxpropyl methylcellulose were done. Different paracetamol suspensions using kollidon CL-M, tragacanth, hydroxpropyl methylcellulose (HPMC) and acacia were prepared and effect of type and concentration of suspending agent on sedimentation volume and redispersibility. Various batches of paracetamol suspension prepared using kollidon CL-M, compound tragacanth, HPMC and acacia were evaluated for sedimentation volume and redispersibility. The sedimentation of the formulation increased with increase in tragacanth concentration and results obtained shows that the tragacanth has good and stable suspending properties. It was concluded that tragacanth can be employed as stabilizer and thickener of choice for paracetamol suspension.
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